23S_ribosomal_RNA
23S ribosomal RNA
A component of the large subunit of the prokaryotic ribosome
The 23S rRNA is a 2,904 nucleotide long (in E. coli) component of the large subunit (50S) of the bacterial/archean ribosome and makes up the peptidyl transferase center (PTC).[2] The 23S rRNA is divided into six secondary structural domains titled I-VI, with the corresponding 5S rRNA being considered domain VII.[3] The ribosomal peptidyl transferase activity resides in domain V of this rRNA, which is also the most common binding site for antibiotics that inhibit translation, making it a target for ribosomal engineering.[2] A well-known member of this antibiotic class, chloramphenicol, acts by inhibiting peptide bond formation, with recent 3D-structural studies showing two different binding sites depending on the species of ribosome. Numerous mutations in domains of the 23S rRNA with Peptidyl transferase activity have resulted in antibiotic resistance.[4] 23S rRNA genes typically have higher sequence variations, including insertions and/or deletions, compared to other rRNAs.[5]
This article is missing information about correct Rfam boxes: LSU_rRNA_archaea, LSU_rRNA_bacteria. (December 2020) |
The eukaryotic homolog of the 23S LSU rRNA is the 28S ribosomal RNA, with a region filled by the 5.8S ribosomal RNA.[6]