3,8-dihydrodiligustilide

3,8-Dihydrodiligustilide

3,8-Dihydrodiligustilide

Chemical compound

3,8-Dihydrodiligustilide is a nonsteroidal phytoprogestogen that is found in Ligusticum chuanxiong.[1][2] It is a potent agonist of the progesterone receptor (EC50 = 90 nM).[1] Another compound in the plant, riligustilide, is also a phytoprogestogen, but is almost 1,000-fold less potent and is very weak in comparison (EC50 ≈ 81 μM).[1]

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References

  1. [1]
    Lim LS, Shen P, Gong YH, Yong EL (2006). "Dimeric progestins from rhizomes of Ligusticum chuanxiong". Phytochemistry. 67 (7): 728–34. Bibcode:2006PChem..67..728L. doi:10.1016/j.phytochem.2006.01.024. PMID 16516938.
  2. [2]
    Ahmed HM, Yeh JY, Lin WJ, Forsberg NE, Cheng WT, Ou BR (2014). "Validation of a luciferase bioassay to detect the progestative activity in gilts whose estrus was induced by an uterotonic herb (Ligusticum chuanxiong)". Livestock Science. 163: 159–164. doi:10.1016/j.livsci.2014.02.012. ISSN 1871-1413.


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