3-hydroxypropionate_dehydrogenase

3-hydroxypropionate dehydrogenase

3-hydroxypropionate dehydrogenase

Class of enzymes

In enzymology, a 3-hydroxypropionate dehydrogenase (EC 1.1.1.59) is an enzyme that catalyzes the chemical reaction

3-hydroxypropanoate + NAD+ 3-oxopropanoate + NADH + H+
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Thus, the two substrates of this enzyme are 3-hydroxypropanoate and NAD+, whereas its 3 products are 3-oxopropanoate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-hydroxypropanoate:NAD+ oxidoreductase. This enzyme participates in beta-alanine metabolism and propanoate metabolism.

References

    • Den H, Robinson WG, Coon MJ (1959). "Enzymatic conversion of beta-hydroxypropionate to malonic semialdehyde". J. Biol. Chem. 234 (7): 1666–1671. PMID 13672942.


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