4-(gamma-L-glutamylamino)butanoyl-(BtrI_acyl-carrier_protein)_monooxygenase

4-(Gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein) monooxygenase

4-(Gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein) monooxygenase

Class of enzymes

4-(gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein) monooxygenase (EC 1.14.14.13, btrO (gene)) is an enzyme with systematic name 4-(gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein),FMN:oxygen oxidoreductase (2-hydroxylating).[1] This enzyme catalyses the following chemical reaction

4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] + FMNH2 + O2 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] + FMN + H2O
Quick Facts Identifiers, EC no. ...

4-(gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein) monooxygenase catalyses a step in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family.

References

  1. [1]
    Li Y, Llewellyn NM, Giri R, Huang F, Spencer JB (June 2005). "Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway". Chemistry & Biology. 12 (6): 665–75. doi:10.1016/j.chembiol.2005.04.010. PMID 15975512.
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