Streatley to Gloucester (M5)

The road runs north-west from Streatley at its junction with the A329 (between Reading and Wallingford) then turns west to Wantage, over the picturesque^[4] Berkshire Downs. In Wantage, it negotiates the market place (around King Alfred's statue). Soon after leaving Wantage it passes through East Challow village and runs north-west to Faringdon, via Stanford in the Vale. It leads on to Lechlade, where it crosses the River Thames at St. John's Bridge. It then runs past the Cotswold Water Park, through the bottleneck of Fairford to Cirencester and thence to Gloucester.

From the start of the Cirencester bypass to Gloucester, the A417 forms part of a major new dual-carriageway route (A419/A417) connecting the M4 (junction 15) with the M5 at Gloucester (junction 11A). At the A429 roundabout on the older Cirencester bypass, the A417 follows the A429 north for 0.5 miles (0.80 km), then resumes when it joins the newer bypass (which is also the A417). The 6-mile (9.7 km) Cirencester & Stratton Bypass opened on 9 December 1997. This route carries traffic between the ports of the south coast and the industrial Midlands. The 4-mile (6.4 km) dual-carriageway north of Stratton to Nettleton Improvement opened on 16 January 1998. ^{[citation needed]} The roundabout at the end of this section often has congestion during peak hours. ^{[citation needed]}

The 2-mile (3.2 km) £2.4m single-carriageway Birdlip bypass opened in December 1988. This point, before the Air Balloon roundabout, has a grand vista of the Severn Valley. After the roundabout and the (now demolished) Air Balloon pub, the road turns sharply and there is a steep gradient. This is a bottleneck at peak times, and there are plans for a dual-carriageway section here. These plans were listed within a roads expansion programme pledged during the government's 2014 Autumn Statement for delivery during the following 5–8 years.^{[5][6][7][needs update]} Construction work to complete the 'missing link' between the end of the Brockworth Bypass and Cowley Roundabout began in 2023, with the expected completion date of Spring 2027. The 3-mile (4.8 km) £36m Brockworth Bypass opened in December 1995, and included the new junction 11a of the M5.

Gloucester (M5) to Hope under Dinmore

Through Gloucester, the road overlaps the A40 Gloucester northern bypass, and from the end of this bypass at a roundabout the road goes north-west through the village of Maisemore, past Hartpury College, then through the village of Hartpury. The A417 then passes through the twin villages of Corse and Staunton. It crosses the M50 Ross Spur motorway at junction 2, then meets the Ledbury bypass, where the road noticeably widens out, and has many large roundabouts. Between Gloucester and Ledbury there are many changes of speed limit. From Ledbury it goes west, overlapping the A438, then at a set of traffic lights known as the Trumpet crossroads, the A417 goes north-west along a more high-hedged, narrow road. It meets the A49 at a wide junction at Hope under Dinmore just south of Leominster.