Originally ran from the A5 at Marble Arch to the A1 at Tally Ho Corner in North Finchley. In 1935 it was extended and rerouted over the A5088 Watford Bypass (the original route became the A598). Renumbered to A41 in the 1950s when it was deemed sensible to give the lower numbers of the bypassed routes to new-build bypasses and radials north of London.

Originally ran from the A5 in Hockliffe to the A508 south of Northampton. Became a southern extension of the A50 in 1935 and has since been downgraded (one section is now B526).

The A511 number also appeared in the "Co-driver: The AA Motorists Companion" (1965) on a route linking the M6 to Wigan. Only the first section east of the M6 was built, however, and it is designated as the A5209.

Used again in the 1990s from Swinscoe to Newcastle-under-Lyme (formerly part of the A52). This almost immediately became part of the A52 again, as the old route of the A52 reverted to the previous designation of A523.

Originally ran between Newcastle-under-Lyme to Salford; renumbered as a portion of the A34 in 1935. Portions in Manchester are now parts of the A5145, A6010, B5093, and B5117.

Originally ran from Ellsmere Port to the A51 at Backford; extended to the A51/A5032 in Little Sutton by 1929. Renumbered as an extension of the A5032 in 1935.

Used a second time in 1935 for the Barnet Bypass (former A5092 and A5093). After the pre Worboys direction signs were introduced, it was decided to give the route a more unique number to aid navigation, and it became a portion of the A1 in 1954. Some portions are now the A1(M) and A1001.

The original A563 appeared in the 1922 Road Lists as "Liverpool - Manchester (Proposed new road)"; the route never appeared on any maps nor did it appear on the ground. A 1932 map does show a proposed A road between Walton, Liverpool and Pendlebury, Salford; this opened in 1934 as the A580, although it is likely it took over at least some of the concept of the A563.

Next used in the 1990s to refer to sections of the upgraded A50 (e.g. from Foston to Etwall) before the A50 was rerouted; became part of the A50 in 1998.

Originally ran between Boar's Head and Duxbury Hall; became the A5106, probably early on as the number was recycled in 1934.

Originally ran from Maghull to Scarisbrick; did not appear in the 1922 Road Lists, but was upgraded from the B5196 by the end of the 1920s. Renumbered as an extension of the then-A567 in 1935 and is now the A5147.

Previously allocated to a road from A6 to A510 in Finedon; became a spur of the A510 in 1935, but has since been declassified and is now Obelisk Road.

Previously allocated to a road from Station Road to B5010 via Donington Lane north of Castle Donington; this was declassified in the 1960s.

Originally ran along Ordsall Lane in Salford between the A6 and A5063. Renumbered to the A5066 and B5461 in the 1960s.

Used a second time by 1926 from Hinckley to Stoney Bridge as an upgrade of the B579. The eastern section (along with the A46) was downgraded to the B4069 (now the B4669) due to completion of the M69. The remainder was downgraded in 1990 to the B4669 (an out-of-zone number as it is north of the A5) when the A47 Hinckley bypass opened.

Previously allocated to a road from the A6 via Stricklandgate in Penrith; this became part of the A6 in a one-way pair.

Originally used for the southern half of the Barnet Bypass. Renumbered to the A555 in 1935 and then to a rerouted A1 around 1954.

Originally proposed in 1935 as a renumbering of the eastern end of the A572 between Swinton and Worsley, because it ran parallel to the New Liverpool - East Lancashire Road (the A580). This renumbering never happened, and the route remains the A572. The A5104 was instead used to upgrade a B road with the same number in North Wales.

London Road, previously the former A5 between Emstrey and The Column, created when the original Shrewsbury bypass opened in 1933. Renumbered to A5064 in the 1970s when a new relief route was built around the east side of Shrewsbury; this route took over the A5112 number.

Number also used along Farrar Street in Bangor, but is unknown if the two routes co-existed or not, as no number can be identified for Farrar Street when the A5122 was rerouted.

Previously allocated to a road from Braunstone to Abbey Park, bypassing Leicester to the east; this was the B583 before it was upgraded. Later became part of the A46 and is now unclassified except the northern end, which is now the B5327.

Originally began at Bronham; the section between Bronham and Elstow was declassified in December 2009 when the A428 Bedford Western and Northwest bypass opened, except for one section that is now the B560 and the section along Woburn Road that is now the B531. Some maps claim that the section east of the A600 is also unclassified.