Adenosine_5'-tetraphosphate

Adenosine 5'-tetraphosphate

Adenosine 5'-tetraphosphate

Chemical compound


Adenosine 5′-tetraphosphate, Ap4 or ATPP is a nucleotide. It is produced from ATP and triphosphate (P3) through the action of acetyl—CoA synthetase.[1] Acetyl—CoA synthetase also produces adenosine 5'-pentaphosphate through the reaction of ADP and tetraphosphate (P4).

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Functions

ATPP has been found to play physiological roles in some mammals.

Rabbits

ATPP is a constituent of aqueous humor in rabbits, where it was found to reduce the intraocular pressure.[2]

Rats

ATPP has been suggested to play a regulatory role in rat aorta.


References

  1. Guranowski, A.; Günther Sillero, M.A.; Sillero, A. (1994). "Adenosine 5′-tetraphosphate and adenosine 5′-pentaphosphate are synthesized by yeast acetyl coenzyme A synthetase". J Bacteriol. 176 (10): 2986–90. doi:10.1128/jb.176.10.2986-2990.1994. PMC 205455. PMID 7910605.
  2. Pintor, Jesús; Peláez, Teresa; Peral, Assumpta (February 2004). "Adenosine tetraphosphate, Ap4, a physiological regulator of intraocular pressure in normotensive rabbit eyes". The Journal of Pharmacology and Experimental Therapeutics. 308 (2): 468–473. doi:10.1124/jpet.103.058669. ISSN 0022-3565. PMID 14600249. S2CID 27129583.

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