Adhesin_molecule_(immunoglobulin_-like)

Adhesion molecule (immunoglobulin-like)

Adhesion molecule (immunoglobulin-like)

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In molecular biology, the adhesin molecule (immunoglobulin-like) is a protein domain. This domain is found in mucosal vascular addressin cell adhesion molecule 1 proteins (MAdCAM-1). These are cell adhesion molecules expressed on the endothelium in mucosa that guide the specific homing of lymphocytes into mucosal tissues. MAdCAM-1 belongs to a subclass of the immunoglobulin superfamily (IgSF), the members of which are ligands for integrins.[1] The crystal structure of this domain has been reported; it adopts an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology.[1][2]

Quick Facts Adhes-Ig_like, Identifiers ...

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References

  1. [1]
    Tan K, Casasnovas JM, Liu JH, Briskin MJ, Springer TA, Wang JH (June 1998). "The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition". Structure. 6 (6): 793–801. doi:10.1016/S0969-2126(98)00080-X. PMID 9655832.
  2. [2]
    Dando J, Wilkinson KW, Ortlepp S, King DJ, Brady RL (February 2002). "A reassessment of the MAdCAM-1 structure and its role in integrin recognition" (PDF). Acta Crystallogr. D. 58 (Pt 2): 233–41. doi:10.1107/S0907444901020522. PMID 11807247.
This article incorporates text from the public domain Pfam and InterPro: IPR015169
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