Adrenopause

Adrenopause

Adrenopause

Decline in secretion and levels of adrenal androgens

Not to be confused with Andropause.

Adrenopause is the decline in secretion and levels of adrenal androgens such as dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) from the zona reticularis of the adrenal glands with age.[2][3] Levels of adrenal androgens start to increase around age 7 or 8 years (adrenarche), peak in early adulthood around age 20 to 25 years, and decrease at a rate of approximately 2% per year thereafter, eventually reaching levels of 10 to 20% of those of young adults by age 80 years.[2][1] It is caused by the progressive apoptosis of adrenal androgen-secreting cells and hence involution of the zona reticularis.[2][3] It is analogous to andropause in men and menopause in women, the abrupt or gradual decline in production of sex hormones from the gonads with age.[4]

Levels of DHEA-S, a major adrenal androgen, throughout life in humans.[1]

DHEA can be supplemented or taken as a medication in the form of prasterone to replace adrenal androgens later in life if it is desired.[2] Some clinical studies have found benefits of DHEA supplementation in the elderly and people with adrenal insufficiency.[2]

See also

References

  1. [1]
    Mark A. Sperling (10 April 2014). Pediatric Endocrinology E-Book. Elsevier Health Sciences. pp. 485–. ISBN 978-1-4557-5973-6.
  2. [2]
    J. Larry Jameson; Leslie J. De Groot (25 February 2015). Endocrinology: Adult and Pediatric E-Book. Elsevier Health Sciences. pp. 1838–. ISBN 978-0-323-32195-2.
  3. [3]
    Papierska L (June 2017). "Adrenopause - does it really exist?". Prz Menopauzalny. 16 (2): 57–60. doi:10.5114/pm.2017.68593. PMC 5509973. PMID 28721131.
  4. [4]
    Shlomo Melmed; Kenneth S. Polonsky; P. Reed Larsen; Henry M. Kronenberg (11 November 2015). Williams Textbook of Endocrinology E-Book. Elsevier Health Sciences. pp. 1237–. ISBN 978-0-323-34157-8.



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