The Africa Squadron was a unit of the United States Navy that operated from 1819 to 1861 in the Blockade of Africa to suppress the slave trade along the coast of West Africa. However, the term was often ascribed generally to anti-slavery operations during the period leading up to the American Civil War.

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Africa Squadron
A photograph of the sloop-of-war USS Jamestown (date unknown). She captured two slave ships with the Africa Squadron.
Active	1819–1861
Country	United States of America
Branch	United States Navy
Type	Naval squadron
Role	African Slave Trade Patrol

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The squadron was an outgrowth of the 1819 treaty between the United States and the United Kingdom that was an early step in stopping the trade, and further defined by the Webster–Ashburton Treaty of 1842. Although technically coordinated with a British West Africa Squadron based in Sierra Leone, in practice the American contingent worked on its own.

Matthew Perry was the first commander of the squadron, and based himself in Portuguese Cape Verde.

The squadron was generally ineffective, since the ships were too few, and since much of the trading activity had shifted to the Niger River delta area (present-day Nigeria), which was not being covered. In the two years of Perry's leadership, only one slaver was reported to have been captured, and that ship was later acquitted by a New Orleans court. In the 16 years of squadron operation, only the crews of 19 slave ships went to trial. These slavers were acquitted or only lightly fined. Other commanders, however, were more successful.

The Africa Squadron's cruising area eventually ranged from Cape Frio to the south (about 18 degrees south latitude), to Madeira in the north. However, the squadron's supply depot was in Cape Verde archipelago, approximately 2,500 nautical miles (4,600 kilometers) from the northernmost centers of the slave trade in the Bight of Biafra and southward. The navy department did not move the depot location until 1859, when it was set up at São Paulo de Luanda, in Portuguese Angola, about eight degrees south latitude. At the same time the department put Madeira out of bounds for the squadron.

The majority of the squadron's cruising in its first decade was along the coast of Western Africa, with particular attention to Liberian interests. By the 1850s much of the slave trade in this area had been eliminated by the British, based in their colony at Sierra Leone, as well as the Liberians.

This however, did not stop the board of directors of the American Colonization Society from writing the President of the United States to bolster the Africa Squadron's "fleet" in 1855 in accordance with the Webster-Ashburton treaty in an attempt to crack down on sailors and slavers use of sea-letters to claim American nationality in their attempt to further the slave trade on the African coast.^[1]

• Pacific Squadron
• Home Squadron
• West Indies Squadron
• Mediterranean Squadron
• Brazil Squadron
• North Atlantic Squadron
• East India Squadron
• Zanzibar slave trade
• Indian Ocean slave trade
• Red Sea slave trade