Alan Mackay-Sim AM (16 May 1951 – 4 January 2023) was an Australian biomedical scientist specialising in adult stem cell research, and winner of the 2017 Australian of the Year. Some of his research focused on olfactory ensheathing cells,^[1] which are cells in the human nose that interact with the nervous system to cause a sense of smell.

His research into stem cells contributed to the treatment of spinal cord injuries. The restoration of mobility to Darek Fidyka, a Polish paraplegic man, used research by Mackay-Sim.^[2][3][4]

Mackay-Sim received his PhD from Macquarie University in 1980,^[5] then subsequently studied at the University of Pennsylvania and the University of Wyoming.^[3]

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Mackay-Sim was the director of the National Centre for Adult Stem Cell Research at Griffith University before his retirement in 2015.^[6]

Mackay-Sim was born on 16 May 1951.^[7] He grew up in Roseville, New South Wales,^[3] the third of four brothers.^[8] He attended North Sydney Boys High School.^[9]

Mackay-Sim was married, with two children.^[8]

In 2015,^[10] he was diagnosed with multiple myeloma, and was treated with stem cell transplant.^[6][11][12]

Mackay-Sim retired in 2015, and lived in Currimundi, Queensland.^[8] He died on 4 January 2023, at the age of 71.^[13][14][15]

• Member of the Order of Australia, for "significant service to tertiary education, and to biomedical science", in the 2021 Queen's Birthday Honours.^[16][17]

• Australian of the Year, 2017^[2]
• Queenslander of the Year, 2003^[5]