Albendazole

Albendazole, also known as albendazolum,[1] is a medication used for the treatment of a variety of parasitic worm infestations.[3] It is useful for giardiasis, trichuriasis, filariasis, neurocysticercosis, hydatid disease, pinworm disease, and ascariasis, among other diseases.[3] It is taken orally.[3]

Albendazole
Clinical data
Trade namesAlbenza, Valbazen, Zentel, others
AHFS/Drugs.comMonograph
MedlinePlusa610019
License data
Pregnancy
category
  • AU: D
Routes of
administration
By mouth
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only
  • UK: POM (Prescription only)
  • US: ℞-only (for humans; veterinary suspension and paste are both OTC)[1]
Pharmacokinetic data
Bioavailability<5%[2]
Protein binding70%[2]
MetabolismHepatic[2]
Elimination half-life8-12 hours[2]
ExcretionBile (humans)
Urine (ruminants)
Identifiers
  • Methyl [5-(propylthio)-1H-benzoimidazol-2-yl]carbamate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
NIAID ChemDB
CompTox Dashboard (EPA)
ECHA InfoCard100.053.995
Chemical and physical data
FormulaC12H15N3O2S
Molar mass265.33 g·mol−1
3D model (JSmol)
Melting point208 to 210 °C (406 to 410 °F)
  • CCCSc2ccc1nc(NC(=O)OC)[nH]c1c2
  • InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16) Y
  • Key:HXHWSAZORRCQMX-UHFFFAOYSA-N Y
  (verify)

Common side effects include nausea, abdominal pains, and headaches.[3] Potentially serious side effects include bone marrow suppression which usually improves on stopping the medication.[3] Liver inflammation has been reported and those with prior liver problems are at greater risk.[3] It is pregnancy category C in the United States and category D in Australia, meaning it may cause harm if taken by pregnant women.[3][4] Albendazole is a broad-spectrum antihelminthic agent of the benzimidazole type.[3]

Albendazole was developed in 1975.[5] It is on the World Health Organization's List of Essential Medicines.[6]


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