Alfred Conkling Coxe Sr. (May 20, 1847 – April 15, 1923) was a United States circuit judge of the United States Court of Appeals for the Second Circuit and of the United States Circuit Courts for the Second Circuit and previously was a United States district judge of the United States District Court for the Northern District of New York.

Coxe was born on May 20, 1847, in Auburn, New York. He was a son of the Rev. Samuel Hanson Coxe (1819–1895) and Eliza (née Conkling) Coxe (1822–1868).^[1]

His paternal grandfather was the abolitionist minister Samuel Hanson Cox and his uncle was Arthur Cleveland Coxe, the Episcopal Bishop of Western New York. His maternal grandfather was Alfred Conkling, who served as a U.S. Representative from upstate New York and a judge in the Northern District. He was also a nephew of Roscoe Conkling, who was a U.S. Congressman and Senator from New York.^[2]

Coxe was educated at the Oxford Academy, the Utica Academy before attending Hamilton College. He later received an LL.D. from Columbia University.^[1]

Coxe read law in 1868. He entered private practice in Utica, New York from 1868 to 1882. In 1870 he entered the firm of Conkling, Holmes & Coxe of Utica with his uncle, Roscoe Conkling who was then a U.S. Senator, together with former Judge and U.S. Representative Sidney T. Holmes. He continued in private practice to 1882. He was manager of the Utica State Hospital from 1880 to 1882.^[3]

Coxe was married to Maryette Andrews Doolittle (1852–1947), a daughter of Charles Hutchins Doolittle and Julia Tyler (née Shearman) Doolittle.^[5] Together, they were the parents of five children:

• Gertrude Doolittle Coxe (b. 1878), who married John Trumbull Robinson, a son of Henry Robinson of Hartford, Connecticut, in 1905.^[6]
• Alfred Conkling Coxe Jr. (1884–1970), who also became a federal judge, serving on the United States District Court for the Southern District of New York from 1929 to 1957; he married Helen Emery, a daughter of Woodward Emery of Boston, Massachusetts, in 1913.^[7]
• Isabel Elise Coxe (b. 1883), who married Louis Seabury Weeks, in 1913.^[8]
• Charles Shearman Coxe (1886–1955), who married Helen Osborn, daughter of the Rev. Louis Shreve Osborn of Salem, Massachusetts in 1913.
• Howard Cleveland Coxe (1897–1940), was a newspaperman and novelist.^[9]

Coxe died on April 15, 1923, in Hartford, Connecticut.^[3] His widow died in 1947.^[5]