Antifungal protein family

The antifungal protein family is a protein family, with members sharing a structure consisting of five antiparallel beta strands which are highly twisted creating a beta barrel stabilised by four internal disulphide bridges.[1] A cationic site adjacent to a hydrophobic stretch on the protein surface may constitute a phospholipid binding site.[1]

solution structure of the antifungal protein from aspergillus giganteus. evidence for disulphide configurational isomerism

Human epithelium produce antifungal proteins.[2] The proteins kill fungi by inducing apoptosis and/or forming pores on the cell membrane.[2]

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