Hajduk Split

A product of Hajduk Split academy, Krasimir Balakov handed Milić his first team minutes in the Croatian Cup match against Jadran Gunja but his first league appearance came off the bench on 26 November 2011, in a 2–1 win over Šibenik, aged just 17 years, 8 months and 16 days. He made only one other league appearances that season, also off the bench, but he made another two Cup appearances against Zagreb also. After manager Balakov left Hajduk, new manager Mišo Krstičević came to the Hajduk bench. Since Krstičević managed the Hajduk U-19 team before he knew how to use Milić for the next season. In June 2012 Antonio won the Croatian U-19 championship.

In the 2012–13 Prva HNL, he started as a first team regular. The team's manager, Mišo Krstičević, made Milić a much more stable member of the first team, often playing in the holding midfield role, but also playing as either a central defender or a central midfielder. He played a significant role in defeating Inter Milan 2–0 on San Siro in the 2012–13 UEFA Europa League. He showed great talent while playing in the Prva HNL, and many people consider him on becoming the leading Croatian defender. Antonio Milić and Josip Radošević together created the best double pivot couple in Prva HNL. During Hajduk's winter preparations, he suffered an injury, which kept him off the pitch for nearly two months but he returned and helped his team to reach the 2012–13 Croatian Cup final by scoring the equalizer goal in the away match against Slaven Belupo on Poljud. In May 2013 Antonio signed a new contract with Hajduk that would keep him with the club until 2015. In May 2013 he won the Croatian Cup.

Under new manager Igor Tudor, Antonio's role in the team changed and was somewhat reduced. He was deployed either at left back or at center back and made 22 appearances in all competitions.

Oostende

On 20 December 2014, it was announced that Milić will join the Belgian club K.V. Oostende for a fee of 500 thousand euros.

Anderlecht

After a great three-year display at Oostende, Milić was about to join Anderlecht at the end of January 2018, but failed to sign with them as the transfer could not be completed due to the end of the transfer window. On 22 May 2018, it was announced that Milić has signed a three-year contract with Anderlecht, along with his teammate Knowledge Musona.

Lech Poznań

On 10 January 2021, Milić was transferred from Anderlecht to Polish side Lech Poznań.^[3]

International

As of 18 November 2018^[9]