The Apostolic Vicariate of Derna (Latin: Vicariatus Apostolicus Dernensis) is a Latin Church missionary territory or apostolic vicariate of the Catholic Church in Derna, Libya. It has an episcopal see, but no cathedral.

The apostolic vicariate is exempt to the Holy See, specifically the Congregation for the Evangelization of Peoples) and not part of any ecclesiastical province.

• Established on June 22, 1939 as Apostolic Vicariate of Derna, on territory split from the Apostolic Vicariate of Cyrenaica.

Apostolics Vicar of Derna

• Giovanni Lucato, Salesians (S.D.B.) (September 13, 1939 – June 21, 1948), Titular Bishop of Tigias, later Bishop of Isernia and Venafro (Italy (1948.06.21 – 1962.05.01)
• Apostolic Administrator Giustino Giulio Pastorino, Friars Minor (O.F.M.) (no dates provided), Titular Bishop of Babra, Apostolic Vicar of Benghazi (1965–1997)

• Apostolic Prefecture of Misurata

• GCatholic.org, with incumbent biography links
• Catholic Hierarchy