Aquaporin-1

Aquaporin-1

Aquaporin-1

Protein-coding gene in the species Homo sapiens

Aquaporin 1 (AQP-1) is a protein that in humans is encoded by the AQP1 gene.

Quick Facts AQP1, Available structures ...

AQP-1 is a widely expressed water channel, whose physiological function has been most thoroughly characterized in the kidney. It is found in the basolateral and apical plasma membranes of the proximal tubules, the descending limb of the loop of Henle, and in the descending portion of the vasa recta. Additionally, it is found in red blood cells, vascular endothelium, the gastrointestinal tract, sweat glands, lungs, and the central nervous system.[5]

Neural AQP-1 receptors are regulated by vasopressin AVPR1A receptor activity.[6]

Function

Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as both a molecular water channel protein and as a non-selective cation channel gated by cyclic guanosine monophosphate (cGMP).[7] It is a homotetramer with six bilayer spanning domains and N-glycosylation sites. The AQP1 monomer consists of six transmembrane alpha helices that are connected by five loops (A to E).[8] The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement.[9]

See also

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000240583 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000004655 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Francesca, B.; Rezzani, R. (2010). "Aquaporin and Blood Brain Barrier". Current Neuropharmacology. 8 (2): 92–96. doi:10.2174/157015910791233132. PMC 2923372. PMID 21119879.
  6. [6]
    Rauen K, Pop V, Trabold R, Badaut J, Plesnila N (February 2020). "Vasopressin V1a Receptors Regulate Cerebral Aquaporin 1 after Traumatic Brain Injury". Journal of Neurotrauma. 37 (4): 665–674. doi:10.1089/neu.2019.6653. PMC 7045352. PMID 31547764.
  7. [7]
    Boassa D, Yool AJ (October 2003). "Single amino acids in the carboxyl terminal domain of aquaporin-1 contribute to cGMP-dependent ion channel activation". BMC Physiology. 3: 12. doi:10.1186/1472-6793-3-12. PMC 269983. PMID 14561230.
  8. [8]
    Kong Y, Ma J (December 2001). "Dynamic mechanisms of the membrane water channel aquaporin-1 (AQP1)". Proceedings of the National Academy of Sciences of the United States of America. 98 (25): 14345–9. Bibcode:2001PNAS...9814345K. doi:10.1073/pnas.251507998. PMC 64684. PMID 11717407.
  9. [9]
    "Entrez Gene: AQP1 aquaporin 1 (Colton blood group)".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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