Asperlicin
Asperlicin
Chemical compound
Asperlicin is a mycotoxin, derived from the fungus Aspergillus alliaceus. It acts as a selective antagonist for the cholecystokinin receptor CCKA,[1][2][3] and has been used as a lead compound for the development of a number of novel CCKA antagonists with potential clinical applications.[4][5][6][7] He et al. 1998 present a synthesis from aryl iodide and vinyl iodide.[8]
Quick Facts Names, Identifiers ...
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Preferred IUPAC name
(7S)-7-{[(2S,9S,9aS)-9-Hydroxy-2-(2-methylpropyl)-3-oxo-2,3,9,9a-tetrahydro-1H-imidazo[1,2-a]indol-9-yl]methyl}-6,7-dihydroquinazolino[3,2-a][1,4]benzodiazepine-5,13-dione | |
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Properties | |
C31H29N5O4 | |
Molar mass | 535.593 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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- Van der Bent A, Ter Laak AM, IJzerman AP, Soudijn W. Molecular modelling of asperlicin derived cholecystokinin A receptor antagonists. European Journal of Pharmacology. 1992 Aug 3;226(4):327-34. PMID 1397061
- Nakamura, Itaru; Yamamoto, Yoshinori (2004-02-21). "Transition-Metal-Catalyzed Reactions in Heterocyclic Synthesis". Chemical Reviews. 104 (5). American Chemical Society (ACS): 2127–2198. doi:10.1021/cr020095i. ISSN 0009-2665. PMID 15137788.
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