Barghouti (other spellings Barghuthi, Barghouthi, or Al-Barghuthi) (classical Arabic: البرغوثي al-Barghūthī) is the surname of a prominent Palestinian family. Many of its members are notable figures in Palestinian political and cultural life, and mainly come from Ramallah and al-Bireh Governorate's most prominent towns of Deir Ghassanah, Aboud, Kobar and Bani Zeid.^{[citation needed]}

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• Abd al-Jabir al-Barghouthi, Palestinian commander of the Bani Zeid during the Peasants' revolt in Palestine
• Abdul Latif Barghouti (1928–2002), Palestinian writer and poet
• Abdullah Barghouti (born 1979), Palestinian leading commander in Hamas' armed wing Izz ad-Din al-Qassam Brigades
• Bashir Barghouti (1931–2000), Palestinian communist and journalist
• Bashir Barghouthi (born 1957), Palestinian legal and political activist in the UK.
• Hussein Barghouthi (1954–2002), Palestinian poet and playwright
• Imad Barghouthi (born 1962), Palestinian astrophysicist and public figure, subject to several administrative detentions in Israeli prisons for his political statements, as well as one arrest by the Palestinian Authority.^[1]
• Marwan Barghouthi (born 1958), Palestinian leader of Fatah, jailed by Israel during the Second Intifada
• Mohammad Barghouti, Palestinian former labor minister of the Palestinian Authority
• Mourid Barghouti (born 1944–2021), Palestinian poet and writer
• Mustafa Barghouti (born 1954), Palestinian politician, medical doctor, and one state solution activist
• Nai Barghouti, Palestinian composer and singer
• Omar Barghouti (born 1964), Palestinian activist and co-founder of the BDS movement
• Tamim al-Barghouti (born 1977), Palestinian poet and political scientist, son of Mourid Barghouti.
• Mariam Barghouti (born 1993), Palestinian writer, journalist, and activist