Binding site

In biochemistry and molecular biology, a binding site is a region on a macromolecule such as a protein that binds to another molecule with specificity.[1] The binding partner of the macromolecule is often referred to as a ligand.[2] Ligands may include other proteins (resulting in a protein-protein interaction),[3] enzyme substrates,[4] second messengers, hormones, or allosteric modulators.[5] The binding event is often, but not always, accompanied by a conformational change that alters the protein's function.[6] Binding to protein binding sites is most often reversible (transient and non-covalent), but can also be covalent reversible[7] or irreversible.[8]

Glucose binds to hexokinase in the active site at the beginning of glycolysis.

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