Boldenone
Boldenone
Chemical compound
Boldenone (developmental code name RU-18761), is a naturally occurring anabolic–androgenic steroid (AAS) and the 1(2)-dehydrogenated analogue of testosterone.[3][4][5][6][7] Boldenone itself has never been marketed; as a pharmaceutical drug, it is used as boldenone undecylenate, the undecylenate ester.[3][4][7]
| Clinical data | |
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| Other names | Δ1-Testosterone; 1-Dehydrotestosterone; RU-18761; Androsta-1,4-dien-17β-ol-3-one |
| AHFS/Drugs.com | International Drug Names |
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| Routes of administration | Intramuscular injection |
| Drug class | Androgen; Anabolic steroid |
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| Pharmacokinetic data | |
| Elimination half-life | Intramuscular: 14 days (as boldenone undecylenate)[2] |
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| ECHA InfoCard | 100.011.533  |
| Chemical and physical data | |
| Formula | C19H26O2 |
| Molar mass | 286.415 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 165 °C (329 °F) |
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Pharmacodynamics
Like other AAS, boldenone is an agonist of the androgen receptor (AR).[7] The activity of boldenone is mainly anabolic, with a low androgenic potency. Boldenone will increase nitrogen retention, protein synthesis, increases appetite and stimulates the release of erythropoietin in the kidneys.[8]
Boldenone, also known as Δ1-testosterone, 1-dehydrotestosterone, or androsta-1,4-dien-17β-ol-3-one, is a naturally occurring androstane steroid and a derivative of testosterone.[3][4][7] It is specifically testosterone with a double bond between the C1 and C2 positions.[3][4][7] A related compound is quinbolone, the 17-cyclopentenyl enol ether of boldenone.[3][4]
Sources
Boldenone occurs naturally in the scent gland of Ilybius fenestratus, a species of aquatic beetle.[3]
Ciba reportedly patented boldenone in 1949.[7] It subsequently developed several experimental esters of the drug in the 1950s and 1960s.[7] One of these was boldenone undecylenate, which was introduced for clinical use under the brand name Parenabol and saw some use in the late 1960s and early 1970s.[7] However, it was discontinued before the end of the 1970s.[7] Subsequently, boldenone undecylenate was introduced by Squibb under the brand name Equipose for veterinary use, most commonly in horses.[7]
Generic names
Boldenone is the generic name of the drug and its INNTooltip International Nonproprietary Name and BANTooltip British Approved Name.[3][4][5][6]
Brand names
Boldenone is marketed as veterinary drug as boldenone undecylenate (a derivative of boldenone) under the following brand names: Boldebal H, Equipoise, and Sybolin.[6] It is marketed as a veterinary combination drug with methandriol under the brand name Drive.[6]
In Ukraine, it is marketed for human consumption as the injectable steroid Boldenol.[9]
Doping in sports
There are many known cases of doping in sports with boldenone undecylenate by professional athletes.
- Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-15.
- Ruiz P, Strain EC (2011). Lowinson and Ruiz's Substance Abuse: A Comprehensive Textbook. Lippincott Williams & Wilkins. pp. 358–. ISBN 978-1-60547-277-5.
- Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 640–. ISBN 978-1-4757-2085-3.
- Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 131–. ISBN 978-3-88763-075-1.
- Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 52–. ISBN 978-94-011-4439-1.
- "Boldenone international brand names". Drugs.com. Retrieved 28 April 2017.
- Llewellyn W (2011). Anabolics. Molecular Nutrition Llc. pp. 483–490. ISBN 978-0-9828280-1-4.
- Forbes GB (June 1985). "The effect of anabolic steroids on lean body mass: the dose response curve". Metabolism: Clinical and Experimental. 34 (6): 571–3. doi:10.1016/0026-0495(85)90196-9. PMID 3999979.
- "Boldenol 200 (boldenone undecylenate)". Lyka Labs. Retrieved 15 January 2020.