The Plague of Frogs Cycle

The Bureau was the United States' only defense against an onslaught of frog creatures (originally featured in Seed of Destruction). Though the "frogs" began operating on the East Coast, they spread west on both sides of the US-Canada border. To cut costs, the Bureau moved from its traditional headquarters in Connecticut to an abandoned research facility in Colorado. This facility was last used to house Nazi scientists who defected to America after World War II. As such, the facility contains vast quantities of secret files that the B.P.R.D. has yet to explore.

The frog monster invasion reached its peak during the events of The Black Flame during which a Neo-Nazi madman adopted the persona of the World War II era supervillain the Black Flame and insinuated himself as the leader of the frogs. Together they raised the gigantic Katha-Hem (one of the Ogdru Hem, the 369 spawn of the Ogdru Jahad) which ran rampant across the American heartland until Liz Sherman used an ancient artifact to amplify her pyrokinetic powers a thousandfold. After Katha-Hem was destroyed, the frog monsters dragged the Black Flame into a vast pit and the invasion appeared to come to an end.

A series of incidents—featured in The Warning, The Black Goddess, and King of Fear—saw the Bureau threatened by both an alliance of the frogs, the Black Flame, and creatures from the Hollow Earth, united to bring about an apocalypse and the birth of a new human race; and also the villain Memnan Saa, who abducted Liz in an attempt to use her powers to conquer the Earth so he could prevent the Apocalypse. This crisis saw half of Munich destroyed, the Bureau discredited in the eyes of the American military, and Abe Sapien revealed to be an example of the next stage of the frog's evolution. Finally, Liz Sherman exhausted all of her powers in destroying the underworld alliance. This inadvertently caused massive volcanic disasters across the world, devastating Malaysia and causing the destruction of Borneo (wiping out the nations of Indonesia and Brunei), and also causing the rise of a large, immobile monster in California, spewing out a gas across America and Mexico that mutates people. In the wake of this new crisis, the United Nations Security Council drafted the Bureau to work directly for them, with "blank cheque" funding.

A vision of the future shown in King of Fear showed the apocalypse had triumphed over this larger, more heavily armed B.P.R.D.

The Hell on Earth Cycle

In the wake of the events of King of Fear, the world enters an apocalyptic era as natural disasters and vicious monsters crawl out of the Earth. Society is pushed to the brink of madness as many new cults arise to worship the creatures, while other supernatural forces begin shifting their plans in response to the global chaos. The B.P.R.D. agents face their own struggles during this time - Johann claims revenge on Ben Daimio for the destruction of his new body, while Abe is shot in the head by a panicked psychic girl named Fenix. Fortunately for the B.P.R.D., they gain new allies as well in the form of the Russian Special Sciences Service (S.S.S.), with their director Iosif Nichayko.

Unfortunately, Zinco and the last remnants of Project Ragnarok inadvertently resurrect a new and more powerful Black Flame, who proceeds to take control of New York and reawaken many slumbering Ogdru Hem all over the globe. Abe recovers from his near-fatal wound in time to see the world in an even worse state than last he saw, and he goes AWOL from the B.P.R.D. to go on a journey of self-discovery. Liz regains her powers and rejoins the B.P.R.D., while Johann transfers his spirit into the WWII Sledgehammer suit and together they fight the Ogdru Hem as they run rampant. Eventually they take on the new Black Flame in New York, but their victory only proves hollow as one of the seven Ogdru Jahad lands in Kansas, spawning an army of Ogdru Hem as it tears its way across the land. Johann ends up sacrificing himself to defeat the dragon, paralyzing all the Ogdru Hem around the world and giving the world a moment of peaceful respite.

Enhanced Talents Taskforce

• Hellboy / Anung Un Rama, Cambion (a half-Demon)
• Abraham Sapien, amphibious man
• Elizabeth Sherman, pyrokinetic
• Roger the Homunculus, artificial human
• Johann Kraus, ectoplasmic physical medium
• Captain Benjamin Daimio, were-jaguar
• Panya, ageless mummy
• Fenix Espejo, psychic
• Ted Howards (Gall Dennar), warrior with a Hyperborean sword
• Susan Xiang, psychic
• Josephine T. Gant, psychic
• Garrett Omatta, psychic

Human Agents

• Professor Trevor Bruttenholm, former director (deceased)
• Dr. Tom Manning, director
• Dr. Kate Corrigan, liaison to enhanced talents agents
• Dr. Howard Eaton, occult specialist, assistant to Prof. Bruttenholm
• Professor James Henry O'Donnell, occult specialist
• Andrew Devon, field agent
• Sal Tasso, field agent
• Carla Giarocco, field agent
• Ashley Strode, exorcist and field agent
• Pauline Raskin, former field agent
• Joseph Vaughn, field agent
• Rebecca Gervesh, field agent
• Agent Nichols, field agent
• Agent Enos, field agent
• Rachel Turner, London field agent

Allies

• Sir Edward Grey, Witchfinder, a witch hunter who had his own spin-off series
• Lobster Johnson, a vigilante ghost
• Michael Mathers, also known as The Visitor, an extraterrestrial assassin sent to Earth to kill Hellboy
• Alice Monaghan, a young woman, who was kidnapped by fairies as a baby, then saved by Hellboy, retained some magical abilities and now works as a psychic
• Iosif Nichayko, a Russian zombie super soldier and Director of the Russian Special Sciences Service
• Daryl Tynon, a human hunter who was turned into a wendigo
• Varvara, a little girl possessed by a demon and former director of the Special Sciences Service

Stories

B.P.R.D. began as a series of miniseries, but it also had an ongoing numbering on the inside cover of its issues. For the 100th issue the internal numbering shifted to the front cover as the series became a monthly ongoing comic.

Collected editions

Films

The Bureau appeared in the 2004 film Hellboy and its 2008 sequel Hellboy II: The Golden Army, both directed by Guillermo del Toro, where it differs from the agency in the comics.

• In the film it is a secret United States Government agency, created by Roosevelt to combat Hitler's growing mastery of the occult, and strongly affiliated with the FBI. Professor Bruttenholm claims that the BPRD fought the Occult Wars that ended in 1958 with the death of Adolf Hitler.
• Several personnel are federal agents, including Manning and new character Special Agent John Myers whilst the director is still Professor Bruttenholm, who refers to the bureau as "the ones who bump back", in reference to "things that go bump in the night".
• The BPRD uses the motto "In Absentia Luci, Tenebrae Vincunt", Latin for "In the Absence of Light, Darkness Prevails"—though this motto is grammatically incorrect—Luci should read "Lucis" for the desired meaning.^{[original research?]}
• In Hellboy II: The Golden Army, the Bureau's existence is confirmed when Hellboy reveals himself to the media after battling vicious tooth-fairies. The film reveals there is a German branch where Johann was stationed until he became the new director of the US branch.
• In the 2019 reboot, the Bureau is a public multinational agency.
• It is hinted that the base may be related to military base Area 51 as the number 51 appears on the walls.^{[original research?]}

Television

The B.P.R.D. Declassified was a TV special that aired on the FX in 2004.

Roleplaying game

The B.P.R.D. appeared in the Hellboy Sourcebook and Role Playing Game.