Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMKIIα), a.k.a. Ca²⁺/calmodulin-dependent protein kinase II alpha, is one subunit of CamKII, a protein kinase (i.e., an enzyme which phosphorylates proteins) that in humans is encoded by the CAMK2A gene.^[5][6]

Quick Facts CAMK2A, Available structures ...

CAMK2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VZ6, 3SOA, 5IG3
Identifiers
Aliases	CAMK2A, CAMKA, calcium/calmodulin dependent protein kinase II alpha, MRD53, CaMKIINalpha, MRT63, CaMKIIalpha
External IDs	OMIM: 114078 MGI: 88256 HomoloGene: 56577 GeneCards: CAMK2A
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 150,219,491 bp[1] End 150,290,093 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 E1|18 34.41 cM Start 61,058,690 bp[2] End 61,121,224 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amygdala prefrontal cortex Region I of hippocampus proper Brodmann area 9 cingulate gyrus frontal pole orbitofrontal cortex Brodmann area 46 Brodmann area 10 nucleus accumbens Top expressed in superior frontal gyrus olfactory tubercle piriform cortex subiculum primary motor cortex nucleus accumbens entorhinal cortex Region I of hippocampus proper triceps brachii muscle medial geniculate nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein homodimerization activity kinase activity protein binding glutamate receptor binding ATP binding metal ion binding protein serine/threonine kinase activity calmodulin binding calmodulin-dependent protein kinase activity calcium-dependent protein serine/threonine kinase activity identical protein binding Cellular component endocytic vesicle membrane cytosol membrane plasma membrane synapse nucleoplasm cell junction presynaptic membrane nucleus cytoplasm mitochondrion postsynaptic density neuron projection calcium- and calmodulin-dependent protein kinase complex dendrite cell projection dendritic spine postsynaptic membrane Schaffer collateral - CA1 synapse Biological process phosphorylation interferon-gamma-mediated signaling pathway G1 phase angiotensin-activated signaling pathway positive regulation of cardiac muscle cell apoptotic process regulation of neurotransmitter secretion regulation of mitochondrial membrane permeability involved in apoptotic process MAPK cascade response to ischemia positive regulation of NF-kappaB transcription factor activity regulation of cellular response to heat regulation of neuronal synaptic plasticity protein autophosphorylation calcium ion transport positive regulation of calcium ion transport dendrite morphogenesis Wnt signaling pathway, calcium modulating pathway nervous system development peptidyl-serine phosphorylation peptidyl-threonine phosphorylation cell differentiation intracellular signal transduction protein phosphorylation G1/S transition of mitotic cell cycle dendritic spine development regulation of synaptic vesicle docking peptidyl-threonine autophosphorylation regulation of neuron migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 815 12322 Ensembl ENSG00000070808 ENSMUSG00000024617 UniProt Q9UQM7 P11798 RefSeq (mRNA) NM_171825 NM_015981 NM_001363989 NM_001363990 NM_001369025 NM_001286809 NM_009792 NM_177407 RefSeq (protein) NP_057065 NP_741960 NP_001350918 NP_001350919 NP_001355954 NP_001273738 NP_033922 NP_803126 NP_001390238 NP_001390241 Location (UCSC) Chr 5: 150.22 – 150.29 Mb Chr 18: 61.06 – 61.12 Mb PubMed search [3] [4]
Wikidata
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The product of the CAMK2A gene is an enzyme that belongs to the serine/threonine-specific protein kinase family, as well as the Ca²⁺/calmodulin-dependent protein kinase II subfamily. Ca²⁺ signaling is crucial for several aspects of synaptic plasticity at glutamatergic synapses. This enzyme is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning.^{[citation needed]} In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene.^[7] According to a 2018 study by Bruno Reversade, the recessive mutation of CAMK2A in humans cause a syndrome of severe intellectual disability with growth retardation.^[8]

CAMK2A has been shown to interact with:

• Actinin alpha 4,^[9]
• CDK5R1,^[10] and
• DLG1.^[11]