The calle de Serrano, or simply Serrano, is a street in Madrid, Spain. It is noted as location for luxury flagship stores.^[1]

The urbanisation took off in 1863, with the construction of the first housing in the street.^[2] Initially known as Bulevar Narváez (Narváez Boulevard),^[3] the street received its current name following the 1868 Glorious Revolution, during which the namesake, the General Serrano (who had lived in the street), took a leading role.^[2][3] In the 2010s the street became one the favourite grounds for real estate operations of Venezuelan fortunes.^[4]

The street starts at the Puerta de Alcalá.^[5] Going north across the well-off Salamanca District, historically linked to the upper class and to the presence of luxury stores,^[6] Serrano ends at the Plaza de la República del Ecuador,^[7] in the junction with the calle del Príncipe de Vergara, in the Chamartín District.