Carbonic_anhydrase_5B,_mitochondrial

Carbonic anhydrase 5B, mitochondrial

Carbonic anhydrase 5B, mitochondrial

Enzyme found in humans

Carbonic anhydrase 5B, mitochondrial is an enzyme that in humans is encoded by the CA5B gene.[5][6]

Quick Facts CA5B, Identifiers ...

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles.[6]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000169239 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000031373 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Fujikawa-Adachi K, Nishimori I, Taguchi T, Onishi S (Aug 1999). "Human mitochondrial carbonic anhydrase VB. cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome x". J Biol Chem. 274 (30): 21228–33. doi:10.1074/jbc.274.30.21228. PMID 10409679.
  6. [6]
    "Entrez Gene: CA5B carbonic anhydrase VB, mitochondrial".

Further reading


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