New York Rangers

After Michigan lost the 2011 NCAA final game, the Rangers signed Hagelin to a professional contract, whereby he joined the Rangers' then-American Hockey League (AHL) affiliate, the Connecticut Whale, for the 2011 Calder Cup playoffs.^[14] He then began the subsequent 2011–12 season playing for the Whale.^[15]

Hagelin made his NHL debut against the Washington Capitals on 25 November 2011, registering an assist on a goal by Brian Boyle for his first NHL point.^[16] Hagelin then scored his first career NHL goal the next day against goaltender Sergei Bobrovsky of the Philadelphia Flyers.^[17]

After Adam Henrique of the New Jersey Devils pulled out of the 2012 NHL All-Star Rookie Showcase due to injury, Hagelin took his spot and was slated to take part in the Fastest Skater challenge during the Skills Competition, ultimately winning the competition after beating Ottawa Senators rookie Colin Greening with the fastest final round time ever recorded, 13.218, later beaten by Jonathan Drouin in 2015. Nevertheless, Hagelin later admitted Rangers teammate Marián Gáborík may be an even faster skater.^[18]

On 15 April 2012, Hagelin received a three-game suspension for elbowing Ottawa Senators captain Daniel Alfredsson in the head during New York's loss in Game 2 of the Eastern Conference Quarterfinals.^[19]

In the 2014–15 season, Hagelin matched his career-high of 17 goals and added 35 points in 82 games for the Presidents' Trophy-winning Rangers. On 24 April 2015, Hagelin scored the series-clinching goal in overtime of Game 5 of the 2015 Eastern Conference Quarterfinals against the Pittsburgh Penguins.

Anaheim Ducks

On 27 June 2015, Hagelin, slated to become a restricted free agent on 1 July, was traded along with two draft picks to the Anaheim Ducks in exchange for Emerson Etem and a second-round selection in the 2015 NHL Entry Draft, which New York used to pick Ryan Gropp.^[20] He was later signed to a four-year contract with the Ducks on 14 August 2015.^[21]

Pittsburgh Penguins

In the 2015–16 season, Hagelin struggled with his new club, failing to reproduce his scoring presence from his tenure with the Rangers. With 12 points in 43 games, Hagelin was traded by the Ducks to the Pittsburgh Penguins in exchange for forward David Perron and defenseman Adam Clendening on 16 January 2016.^[22] Hagelin then went on to produce 27 points in 37 games, helping spark the Penguins' mid-season turnaround with his speed. He was also a key contributor in the playoffs, scoring 16 points en route to a 2016 Stanley Cup championship.^[23] Hagelin again won the Cup in 2017, defeating the Nashville Predators in six games. Although that season was marred by injury and low point production, Hagelin did score the final goal of the playoffs, an empty netter in game six, which sealed the 2–0 victory.

Los Angeles Kings

On 14 November 2018, the Penguins traded Hagelin to the Los Angeles Kings in exchange for Tanner Pearson.^[24] Hagelin's time with the Kings was brief and marred by injury, limiting him to just 22 games with the team.

Washington Capitals and retirement

On 21 February 2019, the Kings traded Hagelin to the Washington Capitals in exchange for a third-round pick in the 2019 NHL Entry Draft and a conditional sixth-round pick in the 2020 NHL Entry Draft. The Kings also retained 50% of Hagelin's salary as part of the deal.^[25]

On 16 June 2019, the Capitals re-signed Hagelin to a four-year, $11 million contract extension with an annual average of $2.75 million.^[26]

Hagelin played on the fourth line with Nic Dowd and Garnet Hathaway throughout the 2020–21 NHL season.^[27]

During a Capitals practice on 1 March 2022, Hagelin suffered a severe eye injury, necessitating two surgeries to avoid losing his left eye entirely, and resulting in a partial loss of vision.^[28] The following off-season, Hagelin additionally had an arthroscopic procedure on his hip, ruling him out indefinitely;^[29] this was further followed by a full hip resurfacing in February 2023, his fourth surgery in the span of a year, which resulted in him missing the entire 2022–23 season.^[28][30] Hagelin ultimately announced his retirement on 30 August 2023, citing ongoing complications from his eye injury.^[31]