Carthalo led the Numidian cavalry in a successful skirmish against Rome. In 249, he assisted Adherbal during an attempt by the Romans headed by Publius Claudius Pulcher to take Drepana from the sea. He arrived in the city prior to the siege with 70 quinqueremes. His contribution was recognized for helping force the Romans to abandon the siege despite the superiority of the invading army.
Following the Battle of Cannae, Hannibal sent Carthalo to Rome as a peace envoy. His delegation included a number of Roman prisoners whom the Carthaginians hoped to ransom. However, the newly appointed Roman dictator M. Junius Pera sent a messenger to intercept Carthalo's delegation, telling them to leave by nightfall.
In 209 BC, Carthalo was serving as garrison commander of Tarentum, which had fallen to Hannibal three years earlier, when Q. Fabius Maximus Verrucosus led a Roman force to retake the settlement. In the ensuing battle, when defeat seemed inevitable, Carthalo laid down his arms with the intention of surrendering to Fabius but was killed before he could make contact.
- Huss (1985), p. 562.
- Geus (1994), s.v. "Carthalo".
- Hoyos, Dexter (2015). Mastering the West: Rome and Carthage at War. Oxford: Oxford University Press. pp. 57–58. ISBN 978-0-19-986010-4.
- Bagnall, Nigel (1999). The Punic Wars: Rome, Carthage and the Struggle for the Mediterranean. London: Pimlico. p. 79. ISBN 0-7126-6608-7.
- Hoyos, B. Dexter (2012). Unplanned Wars: The Origins of the First and Second Punic Wars. Berlin: Walter de Gruyter. p. 269. ISBN 978-3-11-015564-8.
- Geus, Klaus (1994), Prosopographie der Literarisch Bezeugten Karthager, Orientalia Lovaniensia Analecta, Vol. 59, Studia Phoenica, No. 13, Leuven: Peeters, ISBN 9789068316438. (in German)
- Huss, Werner (1985), Geschichte der Karthager, Munich: C.H. Beck, ISBN 9783406306549. (in German)
- Lazenby, J.F. (1998), Hannibal's War, Oklahoma City: University of Oklahoma Press, pp. 70, 86, 88, 176, 237, 241, & 285, ISBN 0-8061-3004-0.