Cephem
Cephem
Class of beta-lactam antibiotic
Cephems are a sub-group of β-lactam antibiotics including cephalosporins and cephamycins.[1] It is one of the most common 4-membered ring heterocycle.[2] Produced by actinomycetes, cephamycins were found to display antibacterial activity against a wide range of bacteria, including those resistant to penicillin and cephalosporins.[3] The antimicrobial properties of Cephem include the attachment to certain penicillin-binding proteins that are involved in the production of cell walls of bacteria.[4]