Charles Leigh may refer to:

• Charles Leigh (American football) (1945–2006), National Football League running back
• Charles Leigh (physician) (1662–1701), English physician and naturalist
• Charles Leigh (British Army officer) (1748–1815), British general
• Charles Leigh (librarian) (1871–?), English academic librarian
• Charles Leigh (merchant) (died 1605), English merchant and voyager
• Charles Leigh (1686–1749), British Member of the UK Parliament for Bedfordshire, Warwick, and Higham Ferrers
• Charles Leigh (died 1836), British Member of the UK Parliament for New Ross

• Charles Lee (disambiguation)

This disambiguation page lists articles about people with the same name.
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