Colonel Charles Powell Leslie, JP (1769 – 15 November 1831), of Castle Leslie, Glaslough, County Monaghan, was an Irish landowner and politician.^[1]

He was the eldest son of Charles Powell Leslie and the Hon. Prudence Penelope Hill-Trevor, daughter of Arthur Hill-Trevor, 1st Viscount Dungannon, and therefore, a cousin of the Duke of Wellington. His brothers were the Rt. Rev. John Leslie and Rev. Edward Leslie.^[2] He was educated at Christ Church, Oxford.^[3]

Leslie was Irish Member of Parliament for Monaghan (1801–1826) and New Ross (1830–1831).^[3] He succeeded his father, Charles Powell Leslie, in representing Monaghan. He was Colonel of the County Monaghan militia. He served as High Sheriff of Monaghan in 1788 and Governor until 1831.^[2] He was also trustee of the linen board.^[3]

He was married to Anne (née Ryder), daughter of Rev. Dudley Ryder, from 1791 to her death in 1813, with whom he had three daughters. He married secondly Christiana (née Fosbery), daughter of George Fosbery, of Clorhane, Limerick. By his second wife he had three sons and four daughters, including Charles Powell Leslie, Sir John Leslie, 1st Baronet, Christiana Beresford, Marchioness of Waterford, and Prudentia Penelope Cavendish-Bentinck.^[2]