Charles River is a short river to Boston Harbor, in Massachusetts, United States.

Charles River may also refer to:

• Charles River (Maine) in Maine, United States
• Charles River (Virginia) in Virginia, United States
• Charles River was the name given to the Delaware River by explorers Robert Evelin and Thomas Young in 1634.

• Charles River Associates, a global consulting firm
• Charles River Laboratories, a major US biomedical company
• Charles River Ventures, a venture capital firm

• All pages with titles beginning with Charles River
• All pages with titles containing Charles River

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