Chelsea Manor House was once the demesne of the main manor of the medieval parish now roughly commensurate with the district of Chelsea, London. It was a residence acquired by Henry VIII of England in 1536, and was the site of two subsequent houses. Today, the area is covered by residential streets.

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In 1544, Chelsea was bestowed on Queen Catherine Parr as a lifetime grant, included in her jointure.^[1] She died in 1548 at Sudeley, and in her will she left everything to her fourth husband, Thomas Seymour.

It was home to Elizabeth I of England, as Princess, between 1536 and 1548,^{[citation needed]} and then to Anne of Cleves, who died there in 1557.^{[citation needed]} Other famous owners included James Hamilton, 1st Duke of Hamilton, Charles Cheyne, 1st Viscount Newhaven, Sir Hans Sloane, the Bishops of Winchester.^[2] Three houses in turn existed, the last of which was demolished in 1825 by Earl Cadogan and replaced with fashionable residential streets - the Cadogan family and its enterprises have kept ownership of some of these properties.