Children's Hospital Oakland Research Institute (CHORI) is a biomedical research institute affiliated with California’s pediatric medical center, UCSF Benioff Children's Hospital Oakland.^[1]

CHORI is based in Oakland, California, and operates a 100,000-square-foot (9,300 m²) biomedical research facility^[2] that houses 300 staff members.^{[citation needed]} It includes eight research centers that conduct focused research on cancer, critical care medicine, genetics, immunobiology and vaccine development,^[3] blood and marrow transplantation and cellular therapies, nutrition and metabolism, prevention of obesity, cardiovascular disease and diabetes, sickle cell disease and thalassemia.^[4][2]

The National Institutes of Health is CHORI's primary funding source.^[2][5]

• Center for Cancer
• Center for Critical Care Medicine
• Center for Genetics
• Center for Immunobiology & Vaccine Development
• The Jordan Family Center for Blood and Marrow Transplantation and Cellular Therapies Research
• Center for Nutrition & Metabolism
• Center for Prevention of Obesity, Cardiovascular Disease & Diabetes
• Center for Sickle Cell Disease & Thalassemia

• BACPAC Resource Center
• Cell Sorting
• Elemental Analysis
• Genetic Testing
• Mass Spectrometry
• Microscope Imaging
• Molecular Diagnostics
• Sibling Donor Cord Blood

CHORI’s translational research applications include providing cures for blood diseases, developing new vaccines for infectious diseases, and discovering new treatment protocols for previously fatal or debilitating conditions such as cancers, sickle cell disease and thalassemia, diabetes, asthma, HIV/AIDS, pediatric obesity, nutritional deficiencies, birth defects, hemophilia and cystic fibrosis.^[4][6] CHORI is also a teaching institute^[6] with educational programs for high school, college, doctoral and post-doctoral students.^[7][5]

CHORI is the first research institute in North America to transplant and cure a child with alpha thalassemia major,^{[citation needed]} is a leading center for the use of cord blood and bone marrow transplantation in children with sickle cell anemia and thalassemia, and offers the only not-for-profit Sibling Donor Cord Blood Program in the world.^[4] The Research Institute’s recombinant DNA library contains over 20 million DNA samples that are used in research programs around the world.^{[citation needed]}

CHORI began in 1959 with a small group of scientists and initial financial support from Children’s Hospital Oakland and the family of Lt. Bruce Lyon. Founded as the Bruce Lyon Memorial Research Laboratory (BLMRL), it was the first research laboratory in northern California dedicated exclusively to children’s diseases.^{[citation needed]}

BLMRL was renamed “CHORI,” the research branch of the newly named Children's Hospital & Research Center Oakland, in 1986. In 1999, CHORI moved to the former University High School campus, where it is currently located.^{[citation needed]}