Chile is one of participating countries in the Pan American Games, the largest multi-sport event in the Americas. The Chilean Olympic Committee (COCH) is the National Olympic Committee for the country and the main organizer for its participation at the Pan American Games.

Chile is one of the six countries that has participated in every edition of the Pan American Games since the 1951 edition, even considering the only Winter edition held in 1990.^{[n 1]}

After several failed attempts to organize the Games, Santiago hosted the 2023 Pan American Games. At those Games, Chile won 79 medals, being its most successful participation. The largest amount of gold medals was reached in the 2019 Pan American Games, when Chilean athletes received a total of 13 gold medals.

Chile has hosted the Pan American Games once:

Before 2023, Santiago was expected to host the Pan American Games on different occasions but the events were eventually cancelled:

• 1975 Pan American Games: Santiago was elected unanimously as the host city in 1969. The Games were cancelled in December 1973 by the military junta due to the economic crisis in the country and the turmoil after the coup d'etat. The Games were moved to São Paulo initially, and later to Mexico City.^[1][2]
• 1987 Pan American Games: Santiago was elected by the members of PASO as the host city in 1981. The Games were cancelled later in 1983 by the military junta, due to a severe economic crisis. Quito, the runner-up city, was chosen initially as its replacement, but it cancelled too a few months later. Eventually, Indianapolis was elected as the definitive host city.^[3]
• 1993 Winter Pan American Games: The second edition of the Winter Pan American Games was expected to be held in Santiago. However, the first edition of the Games was not successful and the potential absence of the United States in future editions led to the suspension of the Games.