Chondroitin_4-sulfotransferase

Chondroitin 4-sulfotransferase

Chondroitin 4-sulfotransferase

Class of enzymes

In enzymology, a chondroitin 4-sulfotransferase (EC 2.8.2.5) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenosine-5'-phosphosulfate + chondroitin adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
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Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and chondroitin, whereas its two products are adenosine 3',5'-bisphosphate and chondroitin 4'-sulfate.

This enzyme belongs to the family of transferases, to be specific, the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase. This enzyme is also called chondroitin sulfotransferase. This enzyme participates in 3 metabolic pathways: chondroitin sulfate biosynthesis, sulfur metabolism, and the biosynthesis of glycan structures.

References

    • Habuchi O, Miyashita N (1982). "Separation and characterization of chondroitin 6-sulfotransferase and chondroitin 4-sulfotransferase from chick embryo cartilage". Biochim. Biophys. Acta. 717 (3): 414–21. doi:10.1016/0304-4165(82)90282-3. PMID 6957247.
    • Nakanishi Y, Otsu K, Suzuki S (1983). "Enzymatic transfer of galactosyl phosphate from UDP-galactose to UDP-N-acetylglucosamine". FEBS Lett. 151 (1): 15–8. doi:10.1016/0014-5793(83)80332-9. PMID 6130977.
    • Nakanishi Y, Shimizu M, Otsu K, Kato S, Tsuji M, Suzuki S (1981). "A terminal 6-sulfotransferase catalyzing a synthesis of N-acetylgalactosamine 4,6-bissulfate residue at the nonreducing terminal position of chondroitin sulfate". J. Biol. Chem. 256 (11): 5443–9. PMID 6787041.
    • Suzuki S; Strominger JL (1960). "Enzymatic sulfation of mucopolysaccharides in hen oviduct. I Transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to mucopolysaccharides". J. Biol. Chem. 235: 257–266. PMID 13835879.
    • Suzuki S; Strominger JL (1960). "Enzymatic sulfation of mucopolysaccharides in hen oviduct. II Mechanism of the reaction studied with oligosaccharides and monosaccharides as acceptors". J. Biol. Chem. 235: 267–273. PMID 13835880.
    • Suzuki S; Strominger JL (1960). "Enzymatic sulfation of mucopolysaccharides in hen oviduct. III Mechanism of sulfation of chondroitin and chondroitin sulfate A". J. Biol. Chem. 235: 274–276. PMID 13835881.


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