Familial adenomatous polyposis

Familial adenomatous polyposis (FAP) is a form of hereditary cancer syndrome involving the APC gene located on chromosome q521.^[9] The syndrome was first described in 1863 by Virchow on a 15-year-old boy with multiple polyps in his colon.^[9] The syndrome involves development of multiple polyps at an early age and those left untreated will all eventually develop cancer.^[9] The gene is expressed 100% in those with the mutation and it is autosomal dominant.^[9] 10–20% of patients have negative family history and acquire the syndrome from spontaneous germline mutation.^[9] The average age of newly diagnosed patient is 29 and the average age of newly discovered colorectal cancer is 39.^[9] It is recommended that those affected undergo colorectal cancer screening at younger age with treatment and prevention are surgical with removal of affected tissues.^[9]

Hereditary nonpolyposis colorectal cancer (Lynch Syndrome)

Hereditary nonpolyposis colorectal cancer (HNPCC, also known as Lynch syndrome) is a hereditary colorectal cancer syndrome.^[9] It is the most common hereditary form of colorectal cancer in the United States and accounts for about 3% of all cases of cancer.^[9] It was first recognized by Alder S. Warthin in 1885 at the University of Michigan.^[9] It was later further studied by Henry Lynch who recognized an autosomal dominant transmission pattern with those affected having relatively early onset of cancer (mean age 44 years), greater occurrence of proximal lesions, mostly mucinous or poorly differentiated adenocarcinoma, greater number of synchronous and metachronous cancer cells, and good outcome after surgical intervention.^[9] The Amsterdam Criteria were initially used to define Lynch syndrome before the underlying genetic mechanism had been worked out.^[9] The Criteria required that the patient has three family members all first-degree relatives with colorectal cancer that involves at least two generations with at least one affected person being younger than 50 years of age when the diagnosis was made.^[9] The Amsterdam Criteria is too restrictive and was later expanded to include cancers of endometrial, ovarian, gastric, pancreatic, small intestinal, ureteral, and renal pelvic origin.^[9] The increased risk of cancer seen in patients with by the syndrome is associated with dysfunction of DNA repair mechanism.^[9] Molecular biologists have linked the syndrome to specific genes such as hMSH2, hMSH1, hMSH6, and hPMS2.^[9]

Peutz–Jeghers syndrome

Peutz–Jeghers syndrome is an autosomal dominant syndrome that presents with hamartomatous polyps, which are disorganized growth of tissues of the intestinal tract, and hyperpigmentation of the interlining of the mouth, lips and fingers.^[9] The syndrome was first noted in 1896 by Hutchinson, and later separately described by Peutz, and then again in 1940 by Jeghers.^[9] The syndrome is associated with malfunction of serine-threonine kinase 11 or STK 11 gene, and has a 2–10% increase in risk of developing cancer of the intestinal tract.^[9] The syndrome also causes increased risk of extraintestinal cancer such as that involving breast, ovary, cervix, fallopian tubes, thyroid, lung, gallbladder, bile ducts, pancreas, and testicles.^[9] The polyps often bleeds and may cause obstruction that would require surgery.^[9] Any polyps larger than 1.5 cm needs removal and patients should be monitored closely and screen every two years for malignancy.^[9]

Juvenile polyposis syndrome

Juvenile polyposis syndrome is an autosomal dominant syndrome characterized by increased risk of cancer of intestinal tract and extraintestinal cancer.^[9] It often presents with bleeding and obstruction of the intestinal tract along with low serum albumin due to protein loss in the intestine.^[9] The syndrome is linked to malfunction of SMAD4 a tumor suppression gene that is seen in 50% of cases.^[9] Individuals with multiple juvenile polyps have at least 10% chance of developing malignancy and should undergo abdominal colectomy with ileorectal anastomosis, and close monitoring via endoscopy of rectum.^[9] For individuals with few juvenile polyps, patients should undergo endoscopic polypectomy.^[9]

Comparison table

Hyperplastic polyp

Most hyperplastic polyps are found in the distal colon and rectum.^[18] They have no malignant potential,^[18] which means that they are no more likely than normal tissue to eventually become a cancer.

Neoplastic polyp

A neoplasm is a tissue whose cells have lost normal differentiation. They can be either benign growths or malignant growths. The malignant growths can either have primary or secondary causes. Adenomatous polyps are considered precursors to cancer and cancer becomes invasive once malignant cells cross the muscularis mucosa and invade the cells below.^[9] Any cellular changes seen above the lamina propria are considered non-invasive and are labeled atypia or dysplasia. Any invasive carcinoma that has penetrated the muscularis mocos has the potential for lymph node metastasis and local recurrence which will require more aggressive and extensive resection.^[9] The Haggitt's criteria is used for classification of polyps containing cancer and is based on the depth of penetration.^[9] The Haggitt's criteria has level 0 through level 4, with all invasive carcinoma of sessile polyp variant by definition being classified as level 4.^[9]

• Level 0: Cancer does not penetrate through the muscularis mucosa.^[9]
• Level 1: Cancer penetrates through the muscularis mucosa and invades the submucosa below but is limited to the head of the polyp.^[9]
• Level 2: Cancer invades through with involvement of the neck of polyp.^[9]
• Level 3: Cancer invades through with involvement of any parts of the stalk.^[9]
• Level 4: Cancer invades through the submucosa below the stalk of the polyp but above the muscularis propria of the bowel wall.^[9]

Hamartomatous polyp

Hamartomatous polyps are tumours, like growths found in organs as a result of faulty development. They are normally made up of a mixture of tissues. They contain mucus-filled glands, with retention cysts, abundant connective tissue, and chronic cellular infiltration of eosinophils.^[20] They grow at the normal rate of the host tissue and rarely cause problems such as compression. A common example of a hamartomatous lesion is a strawberry naevus. Hamartomatous polyps are often found by chance; occurring in syndromes such as Peutz–Jegher syndrome or Juvenile polyposis syndrome.

Peutz–Jeghers syndrome is associated with polyps of the GI tract and also increased pigmentation around the lips, genitalia, buccal mucosa feet and hands. People are often diagnosed with Peutz–Jegher after presenting at around the age of nine with an intussusception. The polyps themselves carry little malignant potential but because of potential coexisting adenomas there is a 15% chance of colonic malignancy.

Juvenile polyps are hamartomatous polyps that often become evident before twenty years of age, but can also be seen in adults. They are usually solitary polyps found in the rectum which most commonly present with rectal bleeding. Juvenile polyposis syndrome is characterised by the presence of more than five polyps in the colon or rectum, or numerous juvenile polyps throughout the gastrointestinal tract, or any number of juvenile polyps in any person with a family history of juvenile polyposis. People with juvenile polyposis have an increased risk of colon cancer.^[19]

Inflammatory polyp

These are polyps that are associated with inflammatory conditions such as ulcerative colitis and Crohn's disease.^{[citation needed]}

Gallery

• Microvesicular hyperplastic polyp. H&E stain.
• Microvesicular hyperplastic polyp. H&E stain.
• Traditional serrated adenoma. H&E stain.
• Gross appearance of a colectomy specimen containing two colorectal polyps and one invasive colorectal carcinoma
• Micrograph of a tubular adenoma, the most common type of dysplastic polyp in the colon
• Micrograph of a sessile serrated adenoma. H&E stain.
• Micrograph of a Peutz–Jeghers colonic polyp – a type of hamartomatous polyp. H&E stain.
• Micrograph of a tubular adenoma – dysplastic epithelium (dark purple) on left of image; normal epithelium (blue) on right. H&E stain.
• Micrograph of a villous adenoma. These polyps are considered to have a high risk of malignant transformation. H&E stain.
• Paris classification of colorectal neoplasms^[23]

NICE classification

In colonoscopy, colorectal polyps can be classified by NICE (Narrow-band imaging International Colorectal Endoscopic):^[24]