Cristoforo Madruzzo ([kriˈstɔːforo maˈdruttso]) (5 July 1512 - 5 July 1578)^[1] was an Italian Roman Catholic cardinal and statesman. His brother Eriprando was a mercenary captain who fought in the Italian Wars.

Madruzzo was born on 5 July 1512 at Calavino, into a noble family in Trento. He studied at Padua and Bologna,^[1] received in 1529 from his older brother a canonicate at Trento and the parish of Tirol near Meran, was in 1536 a Canon of Salzburg, in 1537 of Brixen, and in 1539 became Prince-Bishop of Trento.^[2] Being only a subdeacon at the time, he was promoted to the deaconship, priesthood and episcopate in 1542.^[1]

In December 1542, he was appointed administrator of the Bishopric of Brixen,^[3] and shortly afterwards, during the same year, he was raised to the dignity of a cardinal by Pope Paul III. Having resigned his bishopric at Trento in 1567 in favour of his nephew Ludovico, he spent the latter years of his life in Italy, and became Cardinal Bishop successively of Sabina, Palestrina, and Porto.^[1] A few years after his death, his remains were entombed in the family chapel, in the church of Sant'Onofrio, Rome.

Charles V and his brother, King Ferdinand I, afterwards emperor, esteemed him very highly and employed him in many important and delicate missions. He took an active part in the imperial Diet of Ratisbon as representative of the emperor, and upheld strenuously the Catholic teaching against the heresy of Martin Luther.

Madruzzo was also governor of Milan for 20 months.^[4]

In addition to his two sees he received in 1546, by the favour of Charles V, a yearly allowance of 2,000 ducats from the Roman Catholic Archdiocese of Santiago de Compostela in Spain.

He died in Tivoli, Italy, on 5 July 1578, his 66th birthday.

• Carlo Emanuele Madruzzo
• Carlo Gaudenzio Madruzzo