Côme Isaïe Rinfret (September 6, 1847 – November 8, 1911) was a Canadian physician and politician.

Born in Cap-Santé, Portneuf County, Canada East, the son of F. J. Rinfret, Rinfret was educated at the Seminary of Quebec and studied medicine at Victoria University, Montreal from which he graduated with the degree of M.D. He was first elected to the House of Commons of Canada for the electoral district of Lotbinière in the 1878 federal election. A Liberal, he was re-elected in the 1882, 1887, 1891, and 1896 elections. He resigned in 1899 when he was appointed inspector of Inland Revenue.

• Côme Isaïe Rinfret – Parliament of Canada biography
• "Personnel of the Senate and House of Commons, eighth Parliament of Canada, elected June 23, 1896". Internet Archive. 1898.

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