D24(241)-sterol_reductase

Delta24(241)-sterol reductase

Delta24(241)-sterol reductase

Class of enzymes

In enzymology, a Delta24(241)-sterol reductase (EC 1.3.1.71) is an enzyme that catalyzes the chemical reaction

ergosterol + NADP+ ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+
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Thus, the two substrates of this enzyme are ergosterol and NADP+, whereas its 3 products are ergosta-5,7,22,24(241)-tetraen-3beta-ol, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ergosterol:NADP+ Delta24(241)-oxidoreductase. Other names in common use include sterol Delta24(28)-methylene reductase, and sterol Delta24(28)-reductase. This enzyme participates in biosynthesis of steroids.

References

    • Neal WD, Parks LW (1977). "Sterol 24(28) methylene reductase in Saccharomyces cerevisiae". J. Bacteriol. 129 (3): 1375–8. PMC 235112. PMID 14922.
    • Zweytick D, Hrastnik C, Kohlwein SD, Daum G (2000). "Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast saccharomyces cerevisiae". FEBS Lett. 470 (1): 83–7. doi:10.1016/S0014-5793(00)01290-4. PMID 10722850.


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