Deacetoxyvindoline

Desacetoxyvindoline

Desacetoxyvindoline

Chemical compound

Desacetoxyvindoline is a terpene indole alkaloid produced by the plant Catharanthus roseus. Desacetoxyvindoline is a product formed by the methylation of the nitrogen on the indole ring by the enzyme 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase (NMT).[1] The metabolite is a substrate for desacetoxyvindoline 4-hydroxylase (D4H) which catalyzes a hydroxylation to yield deacetylvindoline.[2]

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References

  1. [1]
    Liscombe, DK; Usera, AR; O'Connor, SE (2 November 2010). "Homolog of tocopherol C methyltransferases catalyzes N methylation in anticancer alkaloid biosynthesis". Proceedings of the National Academy of Sciences of the United States of America. 107 (44): 18793–8. Bibcode:2010PNAS..10718793L. doi:10.1073/pnas.1009003107. PMC 2973921. PMID 20956330.
  2. [2]
    Vazquez-Flota, Felipe; De Carolis, Emidio; Alarco, Anne-Marie; De Luca, Vincenzo (1997). "Molecular cloning and characterization of desacetoxyvindoline-4-hydroxylase, a 2-oxoglutarate dependent-dioxygenase involved in the biosynthesis of vindoline in Catharanthus roseus (L.) G. Don". Plant Molecular Biology. 34 (6): 935–948. doi:10.1023/A:1005894001516. PMID 9290645. S2CID 33942703.
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