Decaprenylphospho-beta-D-ribofuranose_2-oxidase

Decaprenylphospho-beta-D-ribofuranose 2-oxidase

Decaprenylphospho-beta-D-ribofuranose 2-oxidase

Add article description

Decaprenylphospho-beta-D-ribofuranose 2-oxidase (EC 1.1.98.3, decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase, Rv3790, DprE1) is an enzyme with systematic name trans,octacis-decaprenylphospho-beta-D-ribofuranose:FAD 2-oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2
Quick Facts Identifiers, EC no. ...

This enzyme from the bacterium Mycobacterium smegmatis participates in epimerization of trans,octacis-decaprenylphospho-beta-D-ribofuranose to trans,octacis-decaprenylphospho-beta-D-arabinoofuranose.

References

  1. [1]
    Ribeiro AL, Degiacomi G, Ewann F, Buroni S, Incandela ML, Chiarelli LR, Mori G, Kim J, Contreras-Dominguez M, Park YS, Han SJ, Brodin P, Valentini G, Rizzi M, Riccardi G, Pasca MR (2011). "Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis". PLOS ONE. 6 (11): e26675. Bibcode:2011PLoSO...626675D. doi:10.1371/journal.pone.0026675. PMC 3206020. PMID 22069462.
  2. [2]
    Trefzer C, Škovierová H, Buroni S, Bobovská A, Nenci S, Molteni E, Pojer F, Pasca MR, Makarov V, Cole ST, Riccardi G, Mikušová K, Johnsson K (January 2012). "Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase DprE1". Journal of the American Chemical Society. 134 (2): 912–5. doi:10.1021/ja211042r. PMID 22188377.


Stub icon

This enzyme-related article is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article Decaprenylphospho-beta-D-ribofuranose_2-oxidase, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.