Demetrios Pepagomenos or Demetrius Pepagomenus (Greek: Δημήτριος Πεπαγωμένος, 1200–1300^[1]) was a Byzantine Greek savant who resided in Constantinople.^[2] He became a physician, a veterinary physician, and a naturalist.^[3]

In 1517, Demetrios Pepagomenos's works on gout were translated and published in Latin by the great post-Byzantine humanist, Marcus Musurus, in Venice.^[7] They were also published in Paris in 1558.^[8]

Demetrios Pepagomenos is lampooned in a 15th-century satire, Mazaris' Journey to Hades, as a doctor who poisoned himself. Mazaris says he had two sons: the older, Saromates ("Lizard Eyes"), also a doctor, and Theodosios the Little Stinker, a social climber.^[9] When Emperor Manuel II Palaeologos (r. 1391–1425) visited the Morea in 1415, Pepagomenos was a doctor in his retinue. He was left at Mystras to serve as court doctor to Theodore II Palaiologos, Despot of the Morea (r. 1407–1443).^[10] In that capacity, he attended the childbed of Cleofe Malatesta Palaiogina in 1433. At her subsequent death, he delivered a funeral oration.^[11]

Pepagomenos may have been the copyist of the medical manuscript Paris gr. 2256.^[12] He was the recipient of letters from John Eugenikos,^[13] and a correspondent of Cardinal Bessarion.^[14]

• Byzantine medicine