The Denali Commission is a federal agency in the US based in Anchorage, Alaska that provides critical utilities, infrastructure, and economic support throughout Alaska.^[1]

It was established in 1998 by the Denali Commission Act of 1998 which was part of an omnibus appropriations bill.^[2][3] Since 2015, it has been assisting Alaskan communities whose existence is threatened by rising sea levels caused by climate change.^{[4][5][6][7][8][9]}

As of 2019, it has a budget of over $46 million.^[10]

Modeled on the Appalachian Regional Commission, the Denali Commission is led by a Federal Co-Chair. Unlike similar commissions, the Federal Co-Chair for the Denali Commission is appointed by the Secretary of Commerce rather than by the President with the advice and consent of the Senate.^[11] As a single state commission, its state co-chair is the Governor of Alaska. The remaining membership consists of the University of Alaska president; the Alaska Municipal League president; the Alaska Federation of Natives president; the Alaska State AFL-CIO president; and the Associated General Contractors of Alaska president.^[11]

• Appalachian Regional Commission, a similar federal-state partnership in Appalachia
• Delta Regional Authority, a similar federal-state partnership in the Mississippi Delta region
• List of micro-regional organizations
• Northern Border Regional Commission, a similar federal-state partnership consisting of areas of Maine, New Hampshire, New York, and Vermont along the Canada–United States border.
• Southeast Crescent Regional Commission
• Tennessee Valley Authority