Denaturation may refer to:

• Denaturation (biochemistry), a structural change in macromolecules caused by extreme conditions
• Denaturation (fissile materials), transforming fissile materials so that they cannot be used in nuclear weapons
• Denaturation (food), intentional adulteration of food or drink rendering it unfit for consumption while remaining suitable for other uses

• Denatured alcohol, also known as methylated spirit
• Denaturalization, the reverse of naturalization, when a state deprives one of its citizens of his or her citizenship

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