Depolarization or depolarizer may refer to:

• Depolarization, a decrease in the absolute value of a cell's membrane potential
• Depolarizer, a substance used to depolarize an electrochemical cell
• Depolarization ratio, the intensity ratio between the parallel component and the perpendicular component of Raman scattered light
• Depolarizer (optics), a device for randomizing the polarization of light

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