The White House deputy chief of staff is officially the top aide to the White House chief of staff, who is the senior aide to the president of the United States. The deputy chief of staff usually has an office in the West Wing and is responsible for ensuring the smooth running of the White House bureaucracy, as well as such other duties as the chief of staff assigns to them. In all recent administrations, there have been multiple deputy chiefs with different duties.

In the Biden administration, there are three current deputy chiefs of staff:

• Anne Tomasini, Deputy Chief of Staff
• Bruce Reed, Deputy Chief of Staff
• Natalie Quillian, Deputy Chief of Staff

Six deputy chiefs of staff were subsequently promoted to become chief of staff: Dick Cheney, Ken Duberstein, Andrew Card, Erskine Bowles, John Podesta, and Joshua Bolten.

• In the NBC television drama The West Wing, the position of White House deputy chief of staff (for strategic planning) was held by Josh Lyman in the fictional Bartlet administration and Sam Seaborn in the fictional Santos administration.
• Chad Lowe portrayed White House deputy chief of staff Reed Pollock, serving under White House chief of staff Tom Lennox and President Wayne Palmer on the television drama 24.
• Adan Canto portrayed the White House deputy chief of staff before being promoted to White House chief of staff in the ABC political drama series Designated Survivor.