Dr. Mark Sloan investigates the hit-and-run death of an ex-con, who was killed by his uncaught accomplice (Robert Guillaume) in his crime, who is now posing as a priest. Mark also has trouble with a homeless woman (Sylvia Sidney) who is hospitalized with an illness that resembles dementia and keeps running off, unaware she witnessed the murder.

A woman arrives at the hospital claiming to be an amnesiac, but Sloan's probing of her past leads him to discover she's a mob assassin and believe that she's plotting to murder a hospitalized senator. However, her actual target is a mob witness posing as a male nurse.

A comedian (Dom DeLuise) who was hosting a telethon for the hospital is murdered, so Sloan investigates.

Dick Martin, Granville Vandusen, Steven Anderson, Dick Van Patten, and Joyce Van Patten also guest star.

A millionaire dies after declaring his intention to leave his money to the hospital - and Sloan suspects the man's offspring.
Note: In addition to Sloan, Dick Van Dyke plays the millionaire Johnathan Nash and his sons Julian Nash and J. Edison Nash and his daughter Judith Nash.

Guest Star: Michael Champion

When a dying man gives him a lottery ticket worth millions, Sloan must fight his way through competing claims in order to give the money to charity.

Guest Star: Ken Kercheval

Steve is framed for the murder of an internal-affairs officer by one of his senior officers, one of a group of four dirty cops involved in drug trade.

Guest Star: Richard Gant, Dennis Lipscomb, John Beck, and Boyd Kestner.

Sloan and Jack use connections to the underworld to expose the dirty cops and figure out which one set up Steve for murder.

Guest Stars: Richard Gant, Boyd Kestner, John Beck, and Don Gordon

Sloan hunts for the stalker of a female pop star who possibly killed a backup singer.

An infomercial financial guru arrives at Mark's house claiming to have been poisoned, dies in the living room, and disappears without a trace. His staff and his wife claim he's still alive, but make excuses as to why Mark never sees him and he suspects something's up. A side gag involves Mark diagnosing and treating a security guard at the studio who has jaw pain.

Guest Stars: Ned Romero

Sloan works to clear a friend in the murder of a magician. Special Guest Star: Emma Samms

Guest Stars: Ray Buktenica, Jack Laufer, and Mitchell Whitfield.

Sloan uses a few leads to find out who's responsible for the death of a dance studio's unfavorable co-owner.

Guest Stars: Paula Marshall, and Kristoff St. John. Watch for a dancer called Shannon, played by Elizabeth Berkley, star of Saved by the Bell and Showgirls.

Amanda is suspected of murdering an old college roommate who had written a tell-all book about her sorority sisters. Mark believes the key to finding the true killer is locating the book before the killer does.

Note: The dog that Amanda adopts she names "Yoda".

When a call girl who was blackmailing some of her clients ends up dead, Mark sorts through her clients to find out who killed her.

Guest Star: Gerald McRaney

After the mayor is murdered, Sloan investigates the peculiar behavior of the politician's widow.

Guest Star: James McEachin, who plays the police Lt. Frank Daniels in six episodes of Matlock (TV series) and Lt. Ed Brock in the Perry Mason TV movies). (He plays a derelict in this episode.)

Sloan follows a few leads to a spa in his investigation of a con man's murder.

A convict that Sloan examines takes everyone at the hospital hostage - and two deaths occur during the situation.

Sloan suspects foul play after a friend dies in an earthquake.

Guest Star: Allan Miller

Sloan comes to suspect that someone could have deliberately exposed a hit man to bubonic plague.

Guest Stars: Julie Sommars (Julie March in the TV Series Matlock), and David Froman (Lieutenant Bob Brooks in Matlock).

Sloan goes undercover as a priest to help a nun catch a murderer in her convent.

Guest Star: Delta Burke