Disease_entity
Endotype
Subtype of a health condition
An endotype is a subtype of a health condition, which is defined by a distinct functional or pathobiological mechanism.[1] This is distinct from a phenotype, which is any observable characteristic or trait of a disease, such as development, biochemical or physiological properties without any implication of a mechanism. It is envisaged that patients with a specific endotype present themselves within phenotypic clusters of diseases.
One example is asthma, which is considered to be a syndrome, consisting of a series of endotypes.[2] This is related to the concept of disease entity.