Disodium_calcium_edetate
Sodium calcium edetate
Chemical compound
Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning,[2] including both short-term and long-term lead poisoning.[3] Sodium calcium edetate came into medical use in the United States in 1953.[3]
| Clinical data | |
|---|---|
| Trade names | Calcium disodium versenate, others |
| Other names | calcium disodium EDTA, edetate calcium disodium, sodium calcium edetate |
| AHFS/Drugs.com | Monograph |
| Routes of administration | IV, IM |
| Drug class | chelating agent |
| ATC code | |
| Legal status | |
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| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
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| UNII | |
| ChEBI | |
| E number | E385 (antioxidants, ...)  |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.000.482 |
| Chemical and physical data | |
| Formula | C10H12CaN2Na2O8 |
| Molar mass | 374.270 g·mol−1 |
| 3D model (JSmol) | |
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Sodium calcium edetate is in the chelating agent family of medication.[3] It is a salt of edetate with two sodium and one calcium atoms.[4] It works by binding to a number of heavy metals, which renders them almost inert and allows them to leave the body in the urine.[3]
Edetate disodium (Endrate) is a different formulation which does not have the same effects.[3]
Medical use
Sodium calcium edetate's primary use is to treat lead poisoning,[2] for which it is an alternative to succimer.[3] It is given by slow injection into a vein or into a muscle.[2]
For lead encephalopathy sodium calcium edetate is typically used together with dimercaprol.[3] It may also be used to treat plutonium poisoning.[5] It does not appear to be useful for poisoning by tetra-ethyl lead.[3]
Side effects
Common side effects include pain at the site of injection.[3] Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure.[2] Benefits when needed in pregnancy are likely greater than the risks.[3]
Sodium calcium edetate came into medical use in the United States in 1953.[3] It is on the World Health Organization's List of Essential Medicines.[6]
- "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
- Stuart MC, Kouimtzi M, Hill SR, eds. (2009). WHO Model Formulary 2008. World Health Organization. pp. 59, 62, 65. hdl:10665/44053. ISBN 9789241547659.
- "Edetate Calcium Disodium". The American Society of Health-System Pharmacists. Archived from the original on 16 January 2017. Retrieved 8 January 2017.
- Kasture AV (2008). Pharmaceutical Chemistry. Vol. I. Pragati Books Pvt. Ltd. p. 16.11. ISBN 9788185790121. Archived from the original on 16 January 2017.
- Flanagan R, Jones A, Maynard RL (2003). Antidotes: Principles and Clinical Applications. CRC Press. p. 47. ISBN 9780203485071. Archived from the original on 16 January 2017.
- Organization WH (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva,CH: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
