Saint Domnina of Syria (Greek: Δομνίνα Συρίας) also known as Domnina the Younger, was a 5th-century ascetic.^[1] Her name is mentioned in the Byzantine Synaxarium.^[1] and according to Theodoret, bishop of Cyrrhus, Domnina was born to a rich Syrian family.^[1]

She became a disciple of Saint Maron.^[2]

As a young woman she constructed a straw-covered hut in the garden of her mother's house, located in Cyrrhus near Antioch.^[3]

She passed all of her life there, to the point where she became extremely thin.^[1] She only ate lentils soaked in water^[2] and went to church in the morning and in the evening. Domnina covered her face in a veil so that no one could see her face.^[2] She had 250 female followers, who passed the time doing manual labor and carding wool.

Theodoret writes, in his Religious History (chap. XXX in Patrologia Graeca), that Domnina acquired such a state of religious ecstasy that she could not speak without weeping as she was considered to have been inspired by the love of God.^[1]

She died between 450 and 460 AD.^[2]